Activating Notch1 mutations in mouse models of T-ALL.

  title={Activating Notch1 mutations in mouse models of T-ALL.},
  author={J O'neil and Jennifer A. Calvo and Keith McKenna and Veena Krishnamoorthy and Jon C Aster and Craig H. Bassing and Frederick W Alt and Michelle Kelliher and A Thomas Look},
  volume={107 2},
Recent studies have demonstrated that most patients with T-cell acute lymphocytic leukemia (T-ALL) have activating mutations in NOTCH1. We sought to determine whether these mutations are also acquired in mouse models of T-ALL. We sequenced the heterodimerization domain and the PEST domain of Notch1 in our mouse model of TAL1-induced leukemia and found that 74% of the tumors harbor activating mutations in Notch1. Cell lines derived from these tumors undergo G(0)/G(1) arrest and apoptosis when… CONTINUE READING
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