Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.

@article{Breit2006ActivatingNM,
  title={Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.},
  author={S. Breit and Martin Stanulla and Thomas Flohr and Martin Schrappe and W G Ludwig and Gabriele Tolle and Margit Happich and Martina U. Muckenthaler and Andreas E Kulozik},
  journal={Blood},
  year={2006},
  volume={108 4},
  pages={1151-7}
}
Activating mutations of the transmembrane receptor NOTCH1 are common in precursor T-cell lymphoblastic leukemia (T-ALL). We systematically analyzed the impact of activating NOTCH1 mutations on early treatment response and long-term outcome in 157 patients with T-ALL of the pediatric ALL-Berlin-Frankfurt-Munster (BFM) 2000 study. We confirm previous results that NOTCH1 mutations occur in more than 50% of T-ALL in children. In 82 patients (82/157; 52.2%), activating NOTCH1 mutations were… CONTINUE READING

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