Activating NOTCH1 Mutations Are Associated with Good Treatment Response in Childhood T-Cell Acute Lymphoblastic Leukemia.

@inproceedings{Breit2005ActivatingNM,
  title={Activating NOTCH1 Mutations Are Associated with Good Treatment Response in Childhood T-Cell Acute Lymphoblastic Leukemia.},
  author={Stephen Breit and Martin Stanulla and Thomas Flohr and Martin Schrappe and W. -D. Ludwig and Gabriele Tolle and Margit Happich and Martina Muckenthaler and Andreas E. Kulozik},
  year={2005}
}
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10–15 % of pediatric ALL. Very rare cases of T-ALL ( NOTCH1 , a gene encoding a single-pass, heterodimeric transmembrane receptor. NOTCH1 has an essential function in early intrathymic T-cell development. Recently, it has been demonstrated that more than 50 % of childhood T-ALLs carry activating mutations within the NOTCH1 gene (Weng et al., Science 2004). In the present study, we systematically analyzed the impact of activating NOTCH1… CONTINUE READING