Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis.

@article{Fasth2010ActivatingNR,
  title={Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis.},
  author={Andreas E. R. Fasth and Niklas K Bj{\"o}rkstr{\"o}m and Minna Anthoni and K J Malmberg and Vivianne Malmstr{\"o}m},
  journal={European journal of immunology},
  year={2010},
  volume={40 2},
  pages={378-87}
}
Effector T-cell responses can be modulated by competing positive or negative signals transduced by NK-cell receptors (NKR). In the CD4(+) T-cell population, the expression of NKR is primarily found in the CD4(+)CD28(-) T-cell subset, also known as CD28(null) T cells. These T cells are frequently found in rheumatoid arthritis (RA) and other inflammatory disorders, suggesting that signaling through NKR may play a role in the autoimmune reaction. Here we aimed to dissect the phenotype and function… CONTINUE READING

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