Activating Mutations of Nand Kras in Multiple Myeloma Show Different Clinical Associations : Analysis of the Eastern Cooperative Oncology Group Phase I 11 Trial

Abstract

Mutations of members of the rasfamily are among the most common oncogene mutations found in multiple myeloma (MM). We have examined the mutational status of the Nand K-res genes at codons 12,13, and 61 in 160 newly diagnosed MM patients enrolled on the Eastern Cooperative Oncology Group (ECOG) phase 111 clinical trial E9486. The total incidence of ras… (More)

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