Activating Mutations in TOR Are in Similar Structures As Oncogenic Mutations in PI3KCα

Abstract

TOR (Target of Rapamycin) is a highly conserved Ser/Thr kinase and a central controller of cell growth. Using the crystal structure of the related lipid kinase PI3KCgamma, we built a model of the catalytic region of TOR, from the FAT domain to near the end of the FATC domain. The model reveals that activating mutations in TOR, identified in yeast in a… (More)
DOI: 10.1021/cb900193e

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