Activating FGFR2-RAS-BRAF mutations in ameloblastoma.

  title={Activating FGFR2-RAS-BRAF mutations in ameloblastoma.},
  author={Noah A. Brown and Delphine Rolland and Jonathan McHugh and Helmut C. Weigelin and Lili Zhao and M. S. Lim and Kojo S. J. Elenitoba-Johnson and Bryan L. Betz},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={20 21},
PURPOSE Ameloblastoma is an odontogenic neoplasm whose overall mutational landscape has not been well characterized. We sought to characterize pathogenic mutations in ameloblastoma and their clinical and functional significance with an emphasis on the mitogen-activated protein kinase (MAPK) pathway. EXPERIMENTAL DESIGN A total of 84 ameloblastomas and 40 non-ameloblastoma odontogenic tumors were evaluated with a combination of BRAF V600E allele-specific PCR, VE1 immunohistochemistry, the Ion… CONTINUE READING
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