Activating CAR and β-Catenin Induces Uncontrolled Liver Growth and Tumorigenesis

  title={Activating CAR and β-Catenin Induces Uncontrolled Liver Growth and Tumorigenesis},
  author={Bingning Dong and Ju-Seog Lee and Y. Park and Feng Yang and Ganyu Xu and Wendong Huang and Milton J. Finegold and David D. Moore},
  booktitle={Nature communications},
Aberrant β-catenin activation contributes to a third or more of human hepatocellular carcinoma (HCC), but β-catenin activation alone is not sufficient to induce liver cancer in mice. Differentiated hepatocytes proliferate upon acute activation of either β-catenin or the nuclear xenobiotic receptor CAR. These responses are strictly limited and are tightly linked, since β-catenin is activated in nearly all of the CAR-dependent tumours generated by the tumour promoter phenobarbital. Here, we show… CONTINUE READING

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