Activating C4-dicarboxylate transporters DcuB and DcuC for improving succinate production

@article{Chen2013ActivatingCT,
  title={Activating C4-dicarboxylate transporters DcuB and DcuC for improving succinate production},
  author={Jing Chen and Xinna Zhu and Zaigao Tan and Hongtao Xu and Jinlei Tang and Dongguang Xiao and Xueli Zhang},
  journal={Applied Microbiology and Biotechnology},
  year={2013},
  volume={98},
  pages={2197-2205}
}
Although many efforts had been performed to engineer Escherichia coli for succinate production, succinate efflux system had not been investigated as an engineering target for improving succinate production. In this work, four Dcu transporters, which had been reported to be responsible for C4-dicarboxylates transportation of E. coli, were investigated for their succinate efflux capabilities. These four dcu genes were deleted individually in a previously constructed succinate-producing strain to… CONTINUE READING