Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease

@article{Fowler2018ActivatingAA,
  title={Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease},
  author={Alan J. Fowler and C. Moussa},
  journal={CNS Drugs},
  year={2018},
  volume={32},
  pages={1-11}
}
Parkinson’s disease is a progressive neurodegenerative disease characterized by Lewy body pathology of which the primary constituent is aggregated misfolded alpha-synuclein protein. Currently, there are no clinical therapies for treatment of the underlying alpha-synuclein dysfunction and accumulation, and the standard of care for patients with Parkinson’s disease focuses only on symptom management, creating an immense therapeutic gap that needs to be filled. Defects in autophagy have been… Expand
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