Activates Wnt / β-catenin Signaling in Ovarian Cancer Lysophosphatidic Acid Initiates Epithelial To Mesenchymal Transition and Induces Beta-Catenin-Mediated Transcription In Epithelial Ovarian Carcinoma

@inproceedings{Burkhalter2015ActivatesW,
  title={Activates Wnt / β-catenin Signaling in Ovarian Cancer Lysophosphatidic Acid Initiates Epithelial To Mesenchymal Transition and Induces Beta-Catenin-Mediated Transcription In Epithelial Ovarian Carcinoma},
  author={Rebecca J. Burkhalter and Suzanne D. Westfall and Yueying Liu and M. Sharon Stack},
  year={2015}
}
During tumor progression, epithelial ovarian cancer (EOC) cells undergo epithelialto-mesenchymal transition (EMT), which influences metastatic success. Mutationdependent activation of Wnt/β-catenin signaling has been implicated in gain of mesenchymal phenotype and loss of differentiation in several solid tumors; however, similar mutations are rare in most EOC histotypes. Nevertheless, evidence for activated Wnt/β-catenin signaling in EOC has been reported and immunohistochemical analysis of… CONTINUE READING

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