Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals.

@article{Bodyak2007ActivatedVD,
  title={Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals.},
  author={Natalya D. Bodyak and Juan Carlos Ayus and Steven G Achinger and Venkatesha Shivalingappa and Qingen Ke and Yee-Shiuan Chen and Debra L Rigor and Isaac E Stillman and Hector Tamez and Paul E. Kroeger and Ruth R Wu-Wong and Siddharth Karumanchi and Ravi I. Thadhani and Peter M. Kang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 43},
  pages={16810-5}
}
Observations in hemodialysis patients suggest a survival advantage associated with activated vitamin D therapy. Left ventricular (LV) structural and functional abnormalities are strongly linked with hemodialysis mortality. Here, we investigated whether paricalcitol (PC, 19-nor-1,25(OH)(2)D(2)), an activated vitamin D compound, attenuates the development of LV abnormalities in the Dahl salt-sensitive (DSS) rat and whether humans demonstrate comparable findings. Compared with DSS rats fed a high… CONTINUE READING

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