Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer.

@article{PedrozaGonzlez2013ActivatedTC,
  title={Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer.},
  author={Alexander Pedroza-Gonz{\'a}lez and Cornelis Verhoef and Jan Nicolaas Maria Ijzermans and Maikel P Peppelenbosch and Jaap Kwekkeboom and Joanne Verheij and Harry L. A. Janssen and Dave Sprengers},
  journal={Hepatology},
  year={2013},
  volume={57 1},
  pages={183-94}
}
UNLABELLED The mechanisms that enable liver cancer to escape elimination by the immune system remain unclear, but their elucidation may provide novel therapeutic interventions. We investigated the influence of tumor-infiltrating regulatory T cells on tumor-specific T cell responses in patients with liver cancer, using ex vivo isolated cells from individuals with hepatocellular carcinoma (HCC) or liver metastases from colorectal cancer (LM-CRC). Here we report that in both HCC and LM-CRC, CD4… CONTINUE READING