Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: possible role of leptin.

  title={Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: possible role of leptin.},
  author={Antonio P{\'e}rez-P{\'e}rez and Julieta L Maym{\'o} and Y{\'e}sica P. Gambino and Pilar Guadix and Jos{\'e} Luis Due{\~n}as and Cecilia Laura Varone and Vı́ctor S{\'a}nchez-Margalet},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={45 6},
Placentas from gestational diabetes (GDM) suffer from structural and functional changes including overgrowth. That is why we aimed to study [³H]-leucine incorporation into protein in addition to translation signaling in placenta from GDM. Thus, we investigated the expression of leptin and leptin receptor (LEPR), as well as the activation state of signaling proteins regulating protein synthesis, such as mTOR, S6 Kinase, EIF4E-BP1, EIF4E, and eEF2 by measuring protein phosphorylation by… CONTINUE READING
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