Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients

@article{Landskron2014ActivatedRA,
  title={Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients},
  author={Johannes Landskron and \Oystein Helland and Knut Martin Torgersen and Einar Martin Aandahl and Bj\orn Tore Gjertsen and Line Bj\orge and Kjetil Task{\'e}n},
  journal={Cancer Immunology, Immunotherapy},
  year={2014},
  volume={64},
  pages={337-347}
}
Invasive ovarian cancer is associated with poor outcome. The presence of infiltrating regulatory T-cells (Tregs) suppresses protective anti-tumor immune responses, and their accumulation into the tumor microenvironment correlates with reduced survival in ovarian cancer patients. Here, we conducted a detailed characterization of CD4+ T-cells, CD8+ T-cells and Treg subsets in the peripheral blood and malignant ascites fluid from seventeen patients with ovarian carcinoma of epithelial origin. Cell… CONTINUE READING
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