Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization.

@article{Rabinovich1998ActivatedRM,
  title={Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization.},
  author={Gabriel A. Rabinovich and Mar{\'i}a Mercedes Iglesias and Nidia M. Modesti and Leonardo F. Castagna and Carlota Wolfenstein-Todel and Clelia Mar{\'i}a Riera and Claudia Sotomayor},
  journal={Journal of immunology},
  year={1998},
  volume={160 10},
  pages={4831-40}
}
Galectins, a family of closely related beta-galactoside-binding proteins, show specific immunomodulatory properties. We have recently identified the presence of a galectin-like protein in rat peritoneal macrophages by means of a cross-reactivity with a polyclonal Ab raised against a galectin purified from adult chicken liver. Galectin expression was up-regulated in inflammatory and activated macrophages, revealing a significant increase in phorbol ester- and formylmethionine oligopeptide… CONTINUE READING
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