Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity.

@article{Sakata1985ActivatedPC,
  title={Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity.},
  author={Yasuhiko Sakata and Scott A. Curriden and Deborah Lawrence and John H. Griffin and David J. Loskutoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 4},
  pages={1121-5}
}
The effects of bovine activated protein C (APC) on the fibrinolytic activity of cultured bovine aortic endothelial cells were investigated. Confluent monolayers were incubated with purified APC under various conditions and changes in total fibrinolytic activity and in the level of plasminogen activator and plasminogen activator inhibitor (antiactivator) were monitored. The addition of APC to the cells in the absence of other blood or plasma components led to a rapid, dose-dependent increase of… CONTINUE READING