Activated protein C resistance testing for factor V Leiden.

  title={Activated protein C resistance testing for factor V Leiden.},
  author={Stephan Kadauke and Bernard Khor and Elizabeth Merrill Van Cott},
  journal={American journal of hematology},
  volume={89 12},
Activated protein C resistance assays can detect factor V Leiden with high accuracy, depending on the method used. Factor Xa inhibitors such as rivaroxaban and direct thrombin inhibitors including dabigatran, argatroban, and bivalirudin can cause falsely normal results. Lupus anticoagulants can cause incorrect results in most current assays. Assays that include dilution into factor V-deficient plasma are needed to avoid interference from factor deficiencies or elevations, which can arise from a… CONTINUE READING


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