Activated protein C resistance--a major risk factor for thrombosis.

@article{Rosen1997ActivatedPC,
  title={Activated protein C resistance--a major risk factor for thrombosis.},
  author={Sabra Rosen and Auguste Sturk},
  journal={European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies},
  year={1997},
  volume={35 7},
  pages={501-16}
}
Resistance to activated protein C is a recently detected phenomenon that has gained a rapid acceptance as a major risk factor for venous thromboembolism. The phenotypic expression of resistance to activated protein C is characterized by a poor response to the anticoagulant activity of activated protein C, a key enzyme in the down-regulation of blood coagulation, which causes a disposition for a hypercoagulable state. At least 90% of the cases with resistance to activated protein C are explained… CONTINUE READING

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