Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.

@article{Uchiba2004ActivatedPC,
  title={Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.},
  author={Mitsuhiro Uchiba and Kenji Okajima and Yuichi Oike and Yasuhiro Ito and Kenji Fukudome and Hirotaka Isobe and Toshio Suda},
  journal={Circulation research},
  year={2004},
  volume={95 1},
  pages={34-41}
}
Activated protein C (APC), a natural anticoagulant, has recently been demonstrated to activate the mitogen-activated protein kinase (MAPK) pathway in endothelial cells in vitro. Because the MAPK pathway is implicated in endothelial cell proliferation, it is possible that APC induces endothelial cell proliferation, thereby causing angiogenesis. We examined this possibility in the present study. APC activated the MAPK pathway, increased DNA synthesis, and induced proliferation in cultured human… CONTINUE READING

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endothelium via binding to endothelial protein C receptor and activation of protease activated receptor - 1

  • RJ Keogh, RA Houliston, Wheeler-Jones CPD
  • 2003

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