Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

@article{Cheng2003ActivatedPC,
  title={Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective},
  author={Tong Cheng and Dong Liu and John H. Griffin and Jos{\'e} Aneiros Fern{\'a}ndez and Francis J. Castellino and Elliot D. Rosen and Kenji Fukudome and Berislav V Zlokovic},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={338-342}
}
Activated protein C (APC) is a systemic anti-coagulant and anti-inflammatory factor. It reduces organ damage in animal models of sepsis, ischemic injury and stroke and substantially reduces mortality in patients with severe sepsis. It was not known whether APC acts as a direct cell survival factor or whether its neuroprotective effect is secondary to its anti-coagulant and anti-inflammatory effects. We report that APC directly prevents apoptosis in hypoxic human brain endothelium through… CONTINUE READING
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