Activated protein C (APC) can increase bone anabolism via a protease-activated receptor (PAR)1/2 dependent mechanism.

@article{Shen2014ActivatedPC,
  title={Activated protein C (APC) can increase bone anabolism via a protease-activated receptor (PAR)1/2 dependent mechanism.},
  author={Kaitlin Shen and Ciara M. Murphy and Ben Chan and Mille Kolind and Tegan L Cheng and Kathy Mikulec and Lauren Peacock and Meilang Xue and Sang-Youel Park and David Graham Little and Christopher J. Jackson and Aaron Schindeler},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2014},
  volume={32 12},
  pages={
          1549-56
        }
}
Activated Protein C (APC) is an anticoagulant with strong cytoprotective properties that has been shown to promote wound healing. In this study APC was investigated for its potential orthopedic application using a Bone Morphogenetic Protein 2 (rhBMP-2) induced ectopic bone formation model. Local co-administration of 10 µg rhBMP-2 with 10 µg or 25 µg APC increased bone volume at 3 weeks by 32% (N.S.) and 74% (p<0.01) compared to rhBMP-2 alone. This was associated with a significant increase in… CONTINUE READING
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