Activated protein C: an emerging therapeutic agent in the prevention of ischemia-reperfusion injury.

Abstract

Free flap necrosis continues to be a significant problem in microvascular surgery. Despite improved microsurgical techniques and equipment, flap loss remains the major operative complication. Although ischemia-induced reperfusion injury remains a significant etiologic factor in flap loss, there is continued interest in endothelial mechanisms that regulate… (More)
DOI: 10.1055/s-2008-1080540

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