Activated prorenin as a therapeutic target for diabetic nephropathy.

@article{Ichihara2008ActivatedPA,
  title={Activated prorenin as a therapeutic target for diabetic nephropathy.},
  author={Atsuhiro Ichihara and Mariyo Sakoda and Asako Mito-Kurauchi and Hiroshi Itoh},
  journal={Diabetes research and clinical practice},
  year={2008},
  volume={82 Suppl 1},
  pages={S63-6}
}
High plasma prorenin levels in diabetic patients predict microvascular complications, but the mechanism of the connection between these factors has remained unclear. (Pro)renin receptors were recently found in the human kidney, and their distribution in the kidneys include the mesangium and podocytes. The binding of prorenin to the (pro)renin receptor triggers two major pathways: the angiotensin II-dependent pathway as a result of the conversion of prorenin to the active form of prorenin… CONTINUE READING