Activated platelets positively regulate RANKL-mediated osteoclast differentiation.

  title={Activated platelets positively regulate RANKL-mediated osteoclast differentiation.},
  author={Barbara Weicht and Philipp Maitz and Barbara Kandler and Michael B. Fischer and Georg Watzek and Reinhard Gruber},
  journal={Journal of cellular biochemistry},
  volume={102 5},
Platelets induce osteoclastogenesis in total bone marrow cultures where hematopoietic cells can interact with stromal cells. Whether or not activated platelets directly act on hematopoietic cells to promote their differentiation into osteoclasts remains unknown. Here we report that platelet releasates (PRS) increase osteoclastogenesis in stroma-depleted, macrophage colony-stimulating factor (M-CSF)-dependent bone marrow cells when cultured in the presence of receptor activator of NF-kappaB… CONTINUE READING

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