Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients.

@article{Danese2003ActivatedPA,
  title={Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients.},
  author={Silvio Danese and Jeffry A. Katz and Simone Saibeni and A Papa and A Gasbarrini and Manuela Vecchi and Carina Fiocchi},
  journal={Gut},
  year={2003},
  volume={52 10},
  pages={1435-41}
}
BACKGROUND The CD40/CD40L system, a key regulator and amplifier of immune reactivity, is activated in inflammatory bowel disease (IBD) mucosa. AIMS To determine whether plasma levels of sCD40L are elevated in Crohn's disease (CD) and ulcerative colitis (UC) patients compared with normal controls, to investigate the cellular source of sCD40L, and to explore CD40L induction mechanisms. PATIENTS CD, UC, and normal control subjects were studied. METHODS The concentration of sCD40L in plasma… CONTINUE READING