Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: results from the GUSTO-I trial.

@article{Granger1996ActivatedPT,
  title={Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: results from the GUSTO-I trial.},
  author={Christopher B. Granger and J. -F. Hirsch and Robert M. Califf and Jacques J. Col and Harvey Douglas White and Amadeo Betriu and Lynn H. Woodlief and Kerry L. Lee and Edwin G. Bovill and Robert J Simes and Eric J. Topol},
  journal={Circulation},
  year={1996},
  volume={93 5},
  pages={870-8}
}
BACKGROUND Although intravenous heparin is commonly used after thrombolytic therapy, few reports have addressed the relationship between the degree of anticoagulation and clinical outcomes. We examined the activated partial thromboplastin time (aPTT) in 29,656 patients in the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO-I) trial and analyzed the relationship between the aPTT and both baseline patient characteristics and clinical outcomes. METHODS AND… CONTINUE READING
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