Activated p38 MAPK is associated with decreased CSF 5-HIAA and increased maternal rejection during infancy in rhesus monkeys

@article{Sanchez2007ActivatedPM,
  title={Activated p38 MAPK is associated with decreased CSF 5-HIAA and increased maternal rejection during infancy in rhesus monkeys},
  author={Mar M Sanchez and Oyetunde Alagbe and Jennifer C. Felger and Jin-yi Zhang and Alice E Graff and Alison P. Grand and Dario Maestripieri Maestripieri and Andrew H. Miller},
  journal={Molecular Psychiatry},
  year={2007},
  volume={12},
  pages={895-897}
}
regulation of RGS4 expression by dopamine and specifically by COMT genotype. Lipska and colleagues showed significantly decreased RGS4 mRNA expression in the DLPFC of Val/Val subjects, relative to Met-carriers. These changes suggest that variation in cortical dopamine may alter RGS4-dependent signaling by regulating its transcription. Alternatively or in addition, genetic variation in RGS4 may become more manifest in COMT Val/Val subjects, whose cortical synaptic dopamine levels are lower. Our… CONTINUE READING

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