Activated oncogenes in B6C3F1 mouse liver tumors: implications for risk assessment.

@article{Reynolds1987ActivatedOI,
  title={Activated oncogenes in B6C3F1 mouse liver tumors: implications for risk assessment.},
  author={Steven H. Reynolds and S J Stowers and Rachel M. Patterson and Robert R. Maronpot and Stuart A. Aaronson and Marshall W. Anderson},
  journal={Science},
  year={1987},
  volume={237 4820},
  pages={1309-16}
}
The validity of mouse liver tumor end points in assessing the potential hazards of chemical exposure to humans is a controversial but important issue, since liver neoplasia in mice is the most frequent tumor target tissue end point in 2-year carcinogenicity studies. The ability to distinguish between promotion of background tumors versus a genotoxic mechanism of tumor initiation by chemical treatment would aid in the interpretation of rodent carcinogenesis data. Activated oncogenes in… CONTINUE READING

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