Activated nuclear factor-kappaB is present in the coronary vasculature in experimental hypercholesterolemia.

@article{Wilson2000ActivatedNF,
  title={Activated nuclear factor-kappaB is present in the coronary vasculature in experimental hypercholesterolemia.},
  author={Stephanie Helen Wilson and Noel M. Caplice and Robert D. Simari and David R. Holmes and Paula J. Carlson and Amir Lerman},
  journal={Atherosclerosis},
  year={2000},
  volume={148 1},
  pages={23-30}
}
BACKGROUND Experimental hypercholesterolemia (HC) is characterized by a decrease in nitric oxide (NO) bioavailability and cellular proliferation. Nuclear factor-kappaB (NF-kappaB) is a transcriptional factor which plays a coordinating role in inflammation and cellular proliferation and may be involved in early atherosclerosis. We examined whether activated NF-kappaB was present in experimental hypercholesterolemia in the coronary vasculature in association with a decrease in NO bioavailability… CONTINUE READING
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