Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.

Abstract

PTEN and PIK3CA mutations occur with high frequency in uterine endometrioid carcinoma (UEC). Although PTEN mutations are present in complex atypical hyperplasia and carcinoma, PIK3CA mutations are restricted to carcinoma. We generated mouse models harboring Pten loss and/or activated Pik3ca in the endometrial epithelium to investigate their respective roles… (More)
DOI: 10.1016/j.ajpath.2014.12.019

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