Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain.

@article{Uchihara1997ActivatedMC,
  title={Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain.},
  author={Toshiki Uchihara and Haruhiko Akiyama and Hiromi Kondo and Ken Ikeda},
  journal={Stroke},
  year={1997},
  volume={28 10},
  pages={1948-50}
}
BACKGROUND AND PURPOSE Microglial cells are present in the center of senile plaques (SPs) in Alzheimer's disease (AD) brain. Such a localization of microglial cells suggests that they are involved in the deposition or the clearance of amyloid-beta protein (A beta) in the brain. We examined their association with another type of parenchymal A beta deposit, which is termed the perivascular deposits of A beta (PA beta). METHODS Thick sections from AD brain were stained with a three-color… CONTINUE READING