Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.

@article{Barbara2004ActivatedMC,
  title={Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.},
  author={G Barbara and Vincenzo Stanghellini and Roberto De Giorgio and Cesare Cremon and Graeme S Cottrell and Donatella Santini and Gianandrea Pasquinelli and Antonio Maria Morselli-Labate and Eileen F. Grady and Nigel W Bunnett and Stephen M. Collins and Roberto Corinaldesi},
  journal={Gastroenterology},
  year={2004},
  volume={126 3},
  pages={693-702}
}
BACKGROUND & AIMS The mechanisms underlying abdominal pain perception in irritable bowel syndrome (IBS) are poorly understood. Intestinal mast cell infiltration may perturb nerve function leading to symptom perception. We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients. METHODS IBS patients were diagnosed according to Rome II criteria and abdominal pain quantified according… CONTINUE READING
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