Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors.

@article{Kenerson2002ActivatedMT,
  title={Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors.},
  author={Heidi L. Kenerson and Lauri D. Aicher and Lawrence D. True and Raymond Yeung},
  journal={Cancer research},
  year={2002},
  volume={62 20},
  pages={5645-50}
}
Disruption of the TSC1 or TSC2 gene leads to the development of tumors in multiple organs, most commonly affecting the kidney, brain, lung, and heart. Recent genetic and biochemical studies have identified a role for the tuberous sclerosis gene products in phosphoinositide 3-kinase signaling. On growth factor stimulation, tuberin, the TSC2 protein, is phosphorylated by Akt, thereby releasing its inhibitory effects on p70S6K. Here we demonstrate that primary tumors from tuberous sclerosis… CONTINUE READING
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