Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs.

@article{Garzetti2014ActivatedMR,
  title={Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs.},
  author={Livia Garzetti and Ramesh Menon and Annamaria Finardi and Alessandra Bergami and Antonio Sica and Gianvito Martino and Giancarlo Comi and Claudia Verderio and Cinthia Farina and Roberto Furlan},
  journal={Journal of leukocyte biology},
  year={2014},
  volume={95 5},
  pages={817-825}
}
MVs are known vehicles of horizontal communication among cells, currently under scrutiny as powerful biomarkers in several pathological processes. The potential advantage of MVs relies on the assumption that their content reflects processes ongoing in pathologically relevant cell types. We have described that MVs of myeloid origin in the CSF are a marker of microglia/macrophage activation. Myeloid cells have different activation types, resulting in diverse functional phenotypes. Knowledge on… CONTINUE READING
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