Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice.

@article{Criscimanna2014ActivatedMC,
  title={Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice.},
  author={Angela Criscimanna and Gina M Coudriet and George K. Gittes and Jon D Piganelli and Farzad Esni},
  journal={Gastroenterology},
  year={2014},
  volume={147 5},
  pages={1106-18.e11}
}
BACKGROUND & AIMS Although the cells that contribute to pancreatic regeneration have been widely studied, little is known about the mediators of this process. During tissue regeneration, infiltrating macrophages debride the site of injury and coordinate the repair response. We investigated the role of macrophages in pancreatic regeneration in mice. METHODS We used a saporin-conjugated antibody against CD11b to reduce the number of macrophages in mice following diphtheria toxin receptor… CONTINUE READING
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