Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity.

@article{Phan1999ActivatedLP,
  title={Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity.},
  author={Cecile L. Phan and Alan W. McMahon and Randall C. Nelson and John F Elliott and Allan G. Murray},
  journal={Journal of immunology},
  year={1999},
  volume={163 8},
  pages={4557-63}
}
In vivo, MHC class I-restricted injury of allogeneic tissue or cells infected by intracellular pathogens occurs in the absence of classical cytolytic effector mechanisms and Ab. Modulation of the target cell adhesion to matrix may be an additional mechanism used to injure vascular or epithelial cells in inflammation. We studied the mechanisms of human umbilical vein endothelial cell (EC) detachment from matrix-coated plastic following contact by concanamycin A-treated lymphocytes as an in vitro… CONTINUE READING