Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide.

@article{Deb1999ActivatedIO,
  title={Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide.},
  author={Suman Deb and Junshun Zhang and Paul E. Gottschall},
  journal={Journal of neuroscience research},
  year={1999},
  volume={55 1},
  pages={
          44-53
        }
}
Prior studies using rat primary hippocampal cultures indicated induction of matrix metalloproteinases (MMPs) in response to beta-amyloid (A beta). Hence, it was of interest to determine whether MMP activity in a human cell line is influenced by A beta. A beta, but not interleukin-1beta (IL-1beta) or lipopolysaccharide (LPS), stimulated an active form of MMP-2 in human U87 glioblastoma cells, as well as increased the expression of the well-known activator of MMP-2, membrane-type (MT)-MMP… CONTINUE READING
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