Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function.

@article{Plessis2013ActivatedIM,
  title={Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function.},
  author={Johannie Du Plessis and H Vanheel and Carl E. I. Janssen and Leonie Roos and Tomas Slavik and Paraskevi I. Stivaktas and M Nieuwoudt and Stefan van Wyk and Warren A Vieira and Etheresia Pretorius and Mervyn Beukes and Ricard Farr{\'e} and J. P. Tack and Wim Laleman and Johan M J Fevery and Frederik Nevens and Tania A Roskams and Schalk Willem van der Merwe},
  journal={Journal of hepatology},
  year={2013},
  volume={58 6},
  pages={1125-32}
}
BACKGROUND & AIMS Bacterial infections commonly occur in decompensated cirrhosis resulting from bacterial translocation from the intestine. We studied the role of intestinal macrophages and the epithelial barrier in cirrhosis. METHODS Forty-four patients with NASH/ASH cirrhosis (decompensated n=29, compensated n=15) and nineteen controls undergoing endoscopy were recruited. Serum was obtained and LPS and LBP levels determined. Intestinal macrophages were characterized by flow cytometry… CONTINUE READING