Activated innate immunity and the involvement of CX3CR1-fractalkine in promoting hematuria in patients with IgA nephropathy.

@article{Cox2012ActivatedII,
  title={Activated innate immunity and the involvement of CX3CR1-fractalkine in promoting hematuria in patients with IgA nephropathy.},
  author={Sharon Natasha Cox and Fabio Sallustio and Grazia Serino and Antonia Loverre and Francesco Pesce and Margherita Gigante and Gianluigi Zaza and Patrizia F. Stifanelli and Nicola Ancona and Francesco Paolo Schena},
  journal={Kidney international},
  year={2012},
  volume={82 5},
  pages={548-60}
}
A hallmark of immunoglobulin A nephropathy (IgAN) is episodes of gross hematuria coinciding with mucosal infections that can represent the disease-triggering event. Here we performed a whole genomic screen of IgAN patients during gross hematuria to clarify the link between mucosal antigens and glomerular hematuria. Modulated genes showed a clear involvement of the intracellular interferon signaling, antigen-presenting pathway, and the immunoproteasome. The mRNA and protein level of the… CONTINUE READING
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CD16+CD56+ cells are a potential culprit for hematuria in IgA nephropathy

Clinical and Experimental Nephrology • 2014
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Plasma fractalkine levels are associated with renal inflammation and outcomes in immunoglobulin A nephropathy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2018

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