Activated human microglia produce the excitotoxin quinolinic acid.

  title={Activated human microglia produce the excitotoxin quinolinic acid.},
  author={Michael Graham Espey and O. Chernyshev and John F. Reinhard and M. A. Aryan Namboodiri and Carol A. Colton},
  volume={8 2},
We aimed to determine the relative role of quinolinic acid synthesis in purified human microglia, monocyte-derived macrophages and astrocytes in the human brain following immune stimulation. Microglia and macrophages significantly increased quinolinic acid synthesis from tryptophan following activation by either lipopolysaccharide or interferon-gamma. Quinolinic acid synthesis by individual microglia was heterogeneous, and its production by activated macrophages was approximately 32-fold… CONTINUE READING


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