Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset.

@article{Novak2001ActivatedHE,
  title={Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset.},
  author={Erik J. Novak and Susan A. Masewicz and Andrew W Liu and Ake Lernmark and William W Kwok and Gerald T Nepom},
  journal={International immunology},
  year={2001},
  volume={13 6},
  pages={799-806}
}
Antigen-specific T cells acquire a distinctive phenotype during activation, with characteristic acquisition of surface markers and patterns of gene expression. Early after antigen stimulation, CD4(+) T lymphocytes increase their surface density of the CD4 marker, a trait which has been used to identify antigen-activated cells. The recent development of MHC tetramer technologies has greatly improved the ability to detect HLA class I-restricted T cells specific for known antigen epitopes. We have… CONTINUE READING

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