Activated human T lymphocytes exhibit reduced susceptibility to methylmercury chloride-induced apoptosis.

@article{Close1999ActivatedHT,
  title={Activated human T lymphocytes exhibit reduced susceptibility to methylmercury chloride-induced apoptosis.},
  author={Abby Close and Tai L. Guo and Bruce J. Shenker},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={1999},
  volume={49 1},
  pages={68-77}
}
Mercurials have been shown to cause apoptosis in human T cells. The objective of this study was to evaluate and compare the relative susceptibility of resting versus activated T cells to methyl mercury chloride (MeHgCl)-induced cell death. Apoptosis was assessed by Hoechst 33258 and 7-AAD staining and annexin V binding. Our results show that activation of T cells by PHA, PMA, and ionomycin, or IL-2, reduces mercury-induced apoptosis by approximately 50%. We have previously shown that the… CONTINUE READING