Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes.

@article{Lane1992ActivatedHT,
  title={Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes.},
  author={Peter B. Lane and Andr{\'e} Traunecker and S Hubele and Seiji Inui and Antonio Lanzavecchia and David T. Gray},
  journal={European journal of immunology},
  year={1992},
  volume={22 10},
  pages={
          2573-8
        }
}
To identify the ligand for the B cell-associated antigen CD40, we constructed a chimeric immunoglobulin molecule where the extracellular portion of the CD40 protein replaced the normal immunoglobulin variable region. No binding was detected on resting peripheral blood T cells. However, following T cell activation with phorbol esters and ionomycin, the chimeric protein bound specifically to activated human T cells and precipitated a 35-kDa protein from such cells. The induction of the CD40… CONTINUE READING

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