Activated human PMN synthesize and release a strongly fucosylated glycoform of alpha1-acid glycoprotein, which is transiently deposited in human myocardial infarction.

@article{Poland2005ActivatedHP,
  title={Activated human PMN synthesize and release a strongly fucosylated glycoform of alpha1-acid glycoprotein, which is transiently deposited in human myocardial infarction.},
  author={Dennis C. W. Poland and Juan-Jes{\'u}s Garc{\'i}a Vallejo and Hans W. M. Niessen and Remco Nijmeyer and Jero Calafat and Cornelis Erik Hack and Bert van het Hof and W. van Dijk},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={78 2},
  pages={453-61}
}
Alpha1-acid glycoprotein (AGP) is a major acute-phase protein present in human plasma as well as in polymorphonuclear leukocytes (PMN). In this report, we show that PMN synthesize a specific glycoform of AGP, which is stored in the specific and azurophilic granules. Activation of PMN results in the rapid release of soluble AGP. PMN AGP exhibits a substantially higher apparent molecular weight than plasma AGP (50-60 kD vs. 40-43 kD), owing to the presence of strongly fucosylated and sialylated… CONTINUE READING

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