Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice.

@article{Zhao2011ActivatedHS,
  title={Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice.},
  author={Wenxiu Zhao and Lei Zhang and Zhenyu Yin and Weixue Su and Guangli Ren and Changsheng Zhou and Junyong You and Jia Fan and Xiaomin Wang},
  journal={International journal of cancer},
  year={2011},
  volume={129 11},
  pages={2651-61}
}
Activated hepatic stellate cells (HSCs) play a central role in the hepatic fibrosis and cirrhosis. Recently, HSCs were reported to have strong immune modulatory activities. However, the role of HSCs in hepatocellular carcinoma (HCC) remains unclear. In this study, we showed that HSCs could promote HCC growth both in vitro and in vivo. We examined the HSC-mediated inhibition of T-cell proliferation and the ability of conditioned medium from activated HSCs to promote the growth of murine HCC cell… CONTINUE READING

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