Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation.

@article{Asai2006ActivatedHS,
  title={Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation.},
  author={Keiko Asai and Susumu Tamakawa and Masahiro Yamamoto and Masumi Yoshie and Yoshihiko Tokusashi and Yuji Yaginuma and Shinichi Kasai and Katsuhiro Ogawa},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2006},
  volume={26 5},
  pages={595-603}
}
BACKGROUND Expression of neurotrophins (NTs) and their receptors is increased during hepatic regeneration, but their role is not well understood. METHODS NTs and their receptors were investigated by RT-PCR and immunostaining in regenerating livers after two-thirds hepatectomy (PH) and in hepatocytes and hepatic stellate cells (HSCs) isolated from regenerating livers in mice. Induction of apoptosis after treatment with NGF and the expression of alpha-smooth muscle actin (SMA), interleukin 6… CONTINUE READING

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