Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.

  title={Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.},
  author={Nicole von Burg and Stephane Chappaz and Anne Baerenwaldt and Edit Horvath and Somdeb Bose Dasgupta and Devika Ashok and J. Pieters and Fabienne Tacchini-Cottier and Antonius G. Rolink and Hans Acha-Orbea and Daniela Finke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 35},
Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation, peripheral ILC3s become activated, secrete cytokines, up-regulate surface MHC class II molecules, and express costimulatory molecules. ILC3s can take up latex beads, process protein antigen, and consequently prime CD4(+) T-cell… CONTINUE READING
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