Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.

@article{Puy2015ActivatedFX,
  title={Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.},
  author={Cristina Puy and Erik Ian Tucker and Anton G Matafonov and Qiufang Cheng and Keith D. Zientek and Dave Gailani and Andr{\'a}s Gruber and Owen J T McCarty},
  journal={Blood},
  year={2015},
  volume={125 9},
  pages={
          1488-96
        }
}
Activation of coagulation factor XI (FXI) may play a role in hemostasis. The primary substrate of activated FXI (FXIa) is FIX, leading to FX activation (FXa) and thrombin generation. However, recent studies suggest the hemostatic role of FXI may not be restricted to the activation of FIX. We explored whether FXI could interact with and inhibit the activity of tissue factor pathway inhibitor (TFPI). TFPI is an essential reversible inhibitor of activated factor X (FXa) and also inhibits the FVIIa… CONTINUE READING
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