Activated epidermal growth factor receptor as a novel target in pancreatic cancer therapy.

@article{Harsha2008ActivatedEG,
  title={Activated epidermal growth factor receptor as a novel target in pancreatic cancer therapy.},
  author={H. C. Harsha and Antonio J. Jimeno and Henrik Molina and Anca B Mihalas and Michael G. Goggins and Ralph H. Hruban and Richard David Schulick and Ullas Kamath and Anirban Maitra and Maartje Hidalgo and Akhilesh Pandey},
  journal={Journal of proteome research},
  year={2008},
  volume={7 11},
  pages={4651-8}
}
Pancreatic cancer is one of the most fatal among all solid malignancies. Targeted therapeutic approaches have the potential to transform cancer therapy as exemplified by the success of several tyrosine kinase inhibitors. Prompted by this, comprehensive profiling of tyrosine kinases and their substrates was carried out using a panel of low passage pancreatic cancer cell lines. One of the pancreatic cancer cell lines, P196, which showed dramatic upregulation of tyrosine kinase activity as… CONTINUE READING